Recently, Dow Chemical's Wolffs Cellulose Division launched the METHOCELDC direct compression grade hypromellose polymer for the first time at the 2009 World Pharmaceutical Raw Materials Japan Show. The product can be used in the direct compression method of matrix tablets in pharmaceutical companies, saving the company about 30% of the production cost. Dow's Wolff Cellulose Division will provide this product through a controlled-release formulation alliance established globally with Colorcon. Domoyuki Sasama, Asia Pacific Marketing Manager, Dow Cornell Fibers Division, said: “Madouxiu direct tablet grade hypromellose polymers have met the economic requirements for the direct tablet production of matrices and their versatility. The performance meets the user's expectations for this long-term proven excipient product. This polymer improves the flow of the overall formulated powder while maintaining excellent compressibility, tablet hardness, and controlled release performance. It is a well-known feature of Midexo products and we believe it will accelerate the innovation process of our customers and create greater value for them.â€
At present, the direct tableting grades available for pharmaceutical companies are METHOCEL K4M Premium DC and METHOCEL K100M Premium DC. Other MDBs for slow release levels are in the process of further development. Dow's Woolf Cellulose Division has made physical improvements to these two polymers in order to optimize the direct tableting effect while retaining the original solution viscosity coefficient, methoxy and hydroxypropyl substituent content And other important attributes that control release-level analogs. These two products have the same chemical properties as the original METHOCEL products to ensure that customers use the globally recognized and approved raw materials. These direct compression grade polymers meet all regulatory requirements of the Japanese Pharmacopoeia, the European Pharmacopoeia and the United States Pharmacopeia.
In recent years, slow and controlled release formulations in China have developed rapidly and have maintained a rapid growth of 30% to 40%. However, bottleneck problems such as high energy consumption and poor fluidity of the granulation process have not been well resolved. Madoux Direct Compression Grade Polymer is a cellulose-based polymer with good compressibility, flowability, physical properties and solubility for tablet formulation, and can be used for controlled release solid dosage forms and oral dosage forms. Direct compression. Due to the abolition of the granulation process, it can help pharmaceutical companies save about 30% of the production cost. It can also avoid the impact of water-sensitive drugs on water during granulation and the possible explosion hazard and patient's allergic influence caused by ethanol granulation. . The introduction of Mitoxiu direct compression grade polymer not only provides a time- and labor-saving solution for the slow and controlled release formulation market, but also “effectively reduces the burden of resident care costs†as determined by the newly launched medical reform program of the Chinese government. Effectively reducing the 'difficult to see a doctor, expensive to see a doctor' and other goals have made tangible contributions.
Dow Chemical’s Wolff Cellulosics Division has been committed to providing innovative solutions for pharmaceuticals to improve human health and continues to deliver on China and Asia Pacific markets. Tomoyuki Sasama said: “We have set up a special R&D center in Shanghai this year. This center has 60 laboratories and will accommodate 600 R&D personnel. One of the laboratories is dedicated to the research and development of pharmaceutical excipients, including oral solids. The research and development of sustained release formulation ingredients, osmotic pump tablets, multiparticulate formulations and HPMC hard capsules will better meet the needs of the Asia-Pacific market by providing products that are closer to customers and provide better, more innovative ideas."
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